Using Mass Spectrometry to Understand the Ageing Population

The UK, like many other countries around the world, is troubled by having an ageing population; meaning a higher population of people aged over 65 than people aged under 16. Improvements in medicine and increased life expectancy have all contributed to the UK’s changing demographic, creating new challenges for future generations.

One such challenge in an ageing population is immunosenescence, this degradation of the immune system, which can increase susceptibility to infection and reduce the effectiveness of vaccinations. Researchers understand that immunosenescence impacts both the innate and adaptive aspects of the immune systems, however, the mechanisms of this break down at a molecular level remains to be unknown. Recent discussions focussed on the ageing population will focus on mass spectrometry and how it can provide insight into age-related infection responses.

Proteomics studies, using samples from the ageing population, will allow the qualitative, quantitative and functional characteristics of all proteins within a sample to be analysed. This method allows researchers to observe entire systems and understand protein crosstalk and mapping of protein content. Mass spec techniques will also reveal protein activation habits and the conditions required to activate or suppress unbound and membrane proteins.

Recent examples of mass spectrum analysis include comparing protein expression between middle-aged (47-62 year old) and elderly (76-82-year old)  samples. The study found 19 protein spot changes which had an affect on; muscle metabolism, ion handling, cellular stress responses and muscle fibre contractions. An additional study also used liquid chromatography-mass spectrometry (LC-MS) to study the effect of age on metabolic processes. Again, 19 protein changes were seen between the young and old samples; those changes caused altered extracellular matrix turnover and a deterioration in immune function, these effects especially seen in cardiovascular tissue.

Continuing to use mass spectrometers to analyse the changes to proteins that occur with age, will allow better preparations to be made for the future.  Understanding protein function through mass spectrometry has already benefited diagnosis techniques, therapy monitoring and drug design. With the UK expected to have an elderly population of 3.5 million by 2034, an understanding of the ageing population is becoming increasingly vital.

Manchester based Mass Spec Technology Solutions Ltd has been manufacturing and providing technical support of mass spectrometers and mass spectrometry instruments for many years.  Our experienced service engineers bring a wide range of expertise offering a fast and efficient service and repair of instruments. Our Mass Spec service team is committed to the ongoing improvement of our services and technology to maximise the performance, throughput and return on investment of your mass spectrometer.

We have a variety of plans to suit individual laboratory requirements, all at an affordable cost and we offer a custom-made service to all our clients.

We offer fully warranted, serviced and refurbished mass spec instruments, installed to maker’s specifications at a fraction of the cost of new instrumentation for your MS Lab.  Refurbished instruments are configured to your requirements with various upgrades available if desired.

Mass Spec has also developed and manufacture a wide range of accessories for mass spectrometers. These include Nitrogen Generators, Noise Suppression Units and MS Lab Benches.

For more information about any of our products or services, please call 0161 9989 219.

Ageing Population

Mass Spectrometry Analysis for Non-Flat Surfaces

Although mass spectrometry has revolutionised analytical science through allowing measurement of chemical species within samples, it has always been incapable of measuring samples from 3D structures such as biological tissues. However, recent work at the Max Planck Institute for Chemical Ecology in Jena may have found a solution. The German based researchers have developed adjustments to an existing mass spectrometry technique to allow analysis on a variety of surfaces including; rippled, bulged, hairy and coarse. It is hoped that once the technique is refined, it will revolutionise the routine measurement of non-flat surfaces.

Laser Ablation Electrospray Ionization (LAESI) is used to measure chemical compounds within biological samples and allow mass spec processes to occur. LAESI uses a laser to target and remove a small fraction of the sample through local heating; this causes the sample to crack open and release chemical vapours. Once these vapours have formed a cloud, the cloud is ionised, and the resulting charged ions can be detected by mass spectrometers.

Adjustments to the LAESI process have resulted in the sampling of non-flat structures. The process has been adapted to measure a height profile of the surface; this is then used to adjust the distance between the focusing lens of the laser and the surface of the sample. The ability to measure samples from three-dimensional surfaces has vast implications, especially within ecology. Efforts are still required to ensure correct preparation of samples for analysis, incorrect handling of samples can change chemical compositions and affect analysis results.

Creators of the adapted LAESI technique, Benjamin Bartles and Aleš Svatoš, comment of the techniques many applications. They detail the ability to compare insect exoskeletons or investigate microbial colonies within their environments. The method will also aid developmental research,  trichome development on leaf surfaces can be analysed through the separate development stages, revealing the chemical composition changes through time.

Manchester based Mass Spec Technology Solutions Ltd has been manufacturing and providing technical support of mass spectrometers and mass spectrometry instruments for many years.  Our Mass Spec service team is committed to the ongoing improvement of our services and technology to maximise the performance, throughput and return on investment of your mass spectrometer.

We offer fully warranted, serviced and refurbished mass spec instruments, installed to maker’s specifications at a fraction of the cost of new instrumentation for your MS Lab.  Refurbished instruments are configured to your requirements with various upgrades available if desired.

Mass Spec has also developed and manufacture a wide range of accessories for mass spectrometers. These include Nitrogen Generators, Noise Suppression Units and MS Lab Benches.

For more information about any of our products or services, please call 0161 9989 219.

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Important Information from Mass Spec Technology Solutions Ltd

It is with regret that we announce that the proposed merger between this company, Mass Spec Technology Solutions Limited and Mass Spec Technologies Limited, a company owned by Barrie Nixon, is now no longer taking place.
 
It had been the intention of both parties that we would join forces with a view to building on each other’s strengths, but unfortunately, insurmountable hurdles have arisen. Accordingly, we confirm that the proposed merger is no longer taking place. It is clear that some companies have been labouring under the miss-apprehension that Mass Spec Technology Solutions Limited has assumed responsibility for those contracts entered into by Mass Spec Technologies Limited. This is not the case. These are and at all times have remained separate trading entities. If you have any queries regarding your contracts with Mass Spec Technologies Limited, please direct your enquiries in the first instance to Barrie Nixon at:-

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07968 096263
 
We can assure you that will not affect in any way our customers and the contracts that we have entered into and all such enquiries should be directed to us as normal.

Fore more information, contact us here or email This email address is being protected from spambots. You need JavaScript enabled to view it.

 

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Season's Greetings from Mass Spec!

All the team at Mass Spec would like to wish their customers a Merry Christmas and a prosperous New Year.  Our premises will close on December 23rd at 1pm and re-open on January 3rd at 8am.

Exciting show for Mass Spec at the 2016 BMSS Meeting

The annual BMSS meeting was once again a great success.  Held in sunny Eastbourne, the event showcased new sessions and three excellent speakers. 

The meeting opened on the evening of Tuesday 13th of September, concluding at 5pm on Thursday 15th.  The meeting also featured a full Exhibition, involving over 30 industrial groups, evening entertainment, a Poster session with prizes and the Conference Dinner.

Mass Spec once again exhibited at the exhibition.  This year they took the SCION 436-GC and SCION 456-GC instruments, as Mass Spec Technology Solutions is the UK distributor of SCION and GCMS instruments. SCION GCs provide the ultimate capability for today’s analytical laboratory. The ultimate in GC platforms can be configured to handle virtually any GC analysis from the most basic single injector/detector to the most complex multi-valve/multi-column. A new platform designed to deliver top performance today and inspire further developments tomorrow. This incorporates legacy instruments of Bruker, Varian, GC and GC/MS.

Mass Spec also exhibited their innovative Lab Bench, NGenMS20.  The innovative design provides a vibration free bench while containing both vacuum pumps and compressed nitrogen generator thus saving lab space.

The new NGenMS20 bench provides a compact solution to lab space and noise suppression requirements.  An integrated CMS based nitrogen generator and vacuum pump noise suppression enclosures save valuable lab floor space and solves lab background noise issues.  An 8 socket, anti-surge power distribution panel and twin lockable castors is supplied as standard and the bench has a high specification noise insulated backing pump enclosure.  Peter Heaps, Manging Director at Mass Spec comments “the conference was fantastic and we are already looking forward to next year’s event which will be held in Manchester I believe so perfect for us!!”

Mass Spec Technology Solutions provides total service support for mass spectrometry laboratories.  Our experienced service team is committed to fast, effective service at affordable cost with a variety of plans to suit individual laboratory requirements.

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