• High Mass Upgrade

High Mass Upgrade

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High mass QToF Ultima

High mass QToF Ultima

QToF Ultima converted to 32kDa range quadrupole to allow native MS analyses..

With the High Mass Upgrade you will be able to:

  • Select and acquire ions up to 30 000 m/z compared to the standard cut off of 4000 m/z. This means that large macromolecules such as GroEL which is 800 kDa can be analyzed (data courtesy of the laboratorium of Albert Heck,Utrecht University).
  • Study large non-covalently bound complexes with maximum transmission and stability due to the fitting of a localised sleeve around the source hexapole.
  • Perform MS/MS experiments on large complexes even at high collision energies to attain the most amount of information.


The High Mass Upgrade package contains a new high mass rf generator and control board, pressure sleeve for the source hexapole and modifications to the gas cell to increase the collision gas pressure to allow full thermalisation of large macromolecules. The package is fitted by a specially trained engineer with a minimum of instrument downtime. No modification to software is necessary.

The High Mass Upgrade is available for all Waters Q-TOFs as well as Quattro LC & Ultima instruments. .

Supporting Documents

High Mass Brochure

High Mass Specification

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